People with systemic lupus erythematosus in Spain now have the option of treating their condition at home, with the arrival of a subcutaneous pre-filled pen version of anifrolumab (Saphnelo), from AstraZeneca.
What is lupus?
Systemic lupus erythematosus is a chronic autoimmune disease in which the immune system attacks the body’s own tissues. It can cause fatigue, joint pain, skin rashes and fever, and in some cases damage organs such as the kidneys or heart. It mainly affects women, often in early adulthood, and typically comes in flare-ups that can make daily life difficult.
The treatment
Anifrolumab works by blocking a receptor involved in the immune system’s overreaction in lupus, helping to reduce disease activity. Until now, it was given as an intravenous infusion in hospital.
From hospital to home
The new pen delivers a 120 mg dose under the skin. After a healthcare professional has confirmed that it is suitable and trained the patient or a carer, the injection can be given at home once a week.
Why it matters
Regular hospital visits for infusions can disrupt work, study and family life. Home treatment:
- reduces the need for trips to hospital;
- gives patients more control over when they take their treatment;
- frees up hospital day-unit resources.
Sticking to treatment
Taking treatment consistently is essential in lupus: missed doses can lead to more flare-ups and a higher risk of lasting organ damage. Studies suggest that a significant proportion of patients miss doses at some point. A simpler format may help.
Tips for using an injection pen
- Wash your hands before handling the pen.
- Inject into a clean area of the thigh, abdomen or upper arm, rotating sites.
- Follow the instructions given by your nurse or doctor.
- Dispose of used pens in a sharps container.
- Keep a record of injection days so as not to miss a dose.
The same medicine
The subcutaneous version is not a new drug, but a new way of giving one that has been available by infusion for several years. For patients with moderate to severe lupus, including those in the Balearics who may live far from hospital, it could mean fewer hospital visits and more flexibility in daily life.
